Increased Levels Of Muellerian-Inhibiting Substance Could Mean Greater Breast Cancer Risk
October 25, 2011
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Healthcare Prof:
Women with increased levels of M???1llerian inhibiting substance (MIS), best recognized for regulating in utero sexual differentiation in boys, might be at a higher risk for breast cancer, according to a new study published online October 9 inside the Journal of the National Cancer Institute .
To determine whether or not MIS levels were related to breast cancer danger, Joanne F. Dorgan, Ph.D., MPH, of the Fox Chase Cancer Center in Philadelphia, and colleagues conducted a prospective case-control study of 309 participants who had been registered in the Columbia, Missouri Serum Bank. Blood samples had been donated by ladies with in situ or invasive breast cancer who, in the time of donation, had been totally free of cancer. Every of 105 breast cancer patients was matched to two control subjects. MIS was measured in serum using an enzyme-linked immunosorbent assay.
Researchers located that growing MIS serum concentrations were associated with increased breast cancer threat in this population.
“Additional analysis is necessary, including confirmatory epidemiological studies on the association of serum MIS with breast cancer and studies aimed at identifying the biological mechanism underlying the association,” the authors write.
Source:
Steve Graff
Journal of the National Cancer Institute
Filed under: French Village